Nodular sclerosis – this histological type of Hodgkin's disease, characterized by a dense growth of connective tissue, dividing into a mass of irregularly shaped cells and slices. They contain proliferating lymphoid matter with a large number of cells Berezovsky-Sternberg. The disease begins with increasing nodes. This pathology is one of the variants of classical Hodgkin's lymphoma.
Hodgkin's Disease is considered a serious ailment that affects the lymphatic system. The disease can occur in any organ that has lymphatic tissue (thymus, tonsils, spleen, adenoids, etc.).
Hodgkin Lymphoma can be a person, if he has symptoms such as:
Chlamydia can be infected at any age, but more often it occurs in young men age category from 16 to 30 years of age or elderly people over 50 years old. Children under 5 years, almost never get sick. What exactly triggers this disease is still unknown. However, there is an assumption that the source-viruses. It is believed that to trigger the beginning of this ailment can:
Nodular sclerosis Hodgkin's lymphoma can take place instantly, lasts from 3 to 6 months or extended up to 20 years.
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The Degree hodinskoe of lymphoma are determined according to the results of laboratory studies and on the basis of the following indicators:
The First stage. In this case, it affects only one lymph node or lymphoid organ (spleen, ring Pirogov-Valdera).
The Second stage. There is usually affected lymph nodes on both sides of the chest, diaphragm and lymphoid organs.
The Third stage. This degree Hodgkin's lymphoma is nearly indistinguishable from second stage. However, it has two kinds of nodular sclerosis third stage:
The Fourth stage. Affects not only nodes, but also non-lymphoid organs-bone marrow, liver, bones, lungs and skin.
Indicator of the severity of the clinical situation and the painful occurrence of other tissues and organs is marked by the letters.
A – severe manifestations of the disease.
B – the presence of one or more symptoms (unjustly increased temperature, sweating at night, rapid weight loss).
E – the lesions spread to the tissues and organs located near the affected lymph nodes.
S – there is loss of the spleen.
X – there is a serious tumor of enormous size.
Regarding the cell structure of chlamydia there are 4 forms of ailments.
Diagnosis "lymphoma" is determined only by the histological examination of the lymph nodes and is proven only in the case when the result of the study revealed the particular multi-Sternberg cells. In severe examples, the need immunophenotyping. Cytological analysis of a lymph node or puncture of the kidney is usually not enough to confirm nodular sclerosis type 1. What needs to be done to establish the diagnosis of the disease:
Contains radiation treatment, surgery and chemotherapy. The choice of the method is set by the stage of illness and the presence of positive or negative prognostic reasons. To the favorable factors include:
If there is not at least one of these causes, then the patient is referred to a group with a poor prognosis.
Complete radiation therapy as an individual form is used for patients with stages IA and IIA, confirmed at laparotomy, and having good prognostic factors. It makes free fields with exposure to all types of affected lymph nodes and passages of the flow of lymph.
The Total absorbed dose in metastatic lesions is 40-45 g over 4-6 weeks in areas of preventive radiation – 30-40 g for 1-4 weeks. Also use multiple methods of wide-field irradiation of certain lesions to prevent nodular sclerosis ns1.
Radiation treatment can cause complications such as fibrosis of the subcutaneous tissue, radiation pulmonic and pericarditis. Deterioration appear in a variety of period – from 3 months to 5 years after therapy. Their complexity depends on the used dose.
Surgical treatment is not often used separately, neobychno is an integral part of therapy in the complex. Perform a splenectomy, as well as operations on the trachea, the esophagus, stomach and other organs (if there is a danger of asphyxia, disorders of the passage of food). Discovered when occurring chlamydia pregnancy should be interrupted.
This type is used as a component of comprehensive treatment. To cure nodular sclerosis, used in different preparations:
Is Used only in special cases with exponential nomination...
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Alin Trodden - author of the article, editor
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