Zoledronic acid: instructions for use, analogs, reviews

Date:

2018-04-02 15:32:24

Views:

541

Rating:

1Like 0Dislike

Share:

Table of contents:

Zoledronic acid, first patented by the Swiss scientists from the firm "Novartis”, at present represented under a variety of names. The drug became widespread as an element of complex therapy of osteochondrosis. It is being used successfully in the treatment of some types of malignant tumors. The tool stops the process of bone resorption. Available are vials containing a white powder or porous mass of absorbent liquid.

Pharmacology

As indicated in the instructions of zoledronic acid, the drug may, in a situation when it is shown aminobisphosphonates. These compounds, and especially considering medicine, have a pronounced selective effect with regard to bone tissue. Scientists have not yet been finally resolved, how it works, by what mechanism affects the human body, but failed to prove that the active substance is an affinity for mineralized bone, and thus may inhibit degenerative processes. At the same time clinical trials have shown that zoledronic acid shows no negative impact on the processes of bone formation, does not adjust its chemical composition, elasticity, thisproject.

Once in the human body, the substance quickly affects the bone marrow at the microscopic level. It suppresses the development of atypical cellular formations. According to the instructions for use, zoledronic acid also eliminates pain and fights tumors. Parallel to the observed inhibition of the formation of endothelial cells. If a cancerous tumor is associated with excess calcium, the concentration of this component under the influence of this means of gradually getting back to normal, which increases the quality of functioning of the vascular system.

Recommended

A tablet from worms – the relevance of the application for the person

A tablet from worms – the relevance of the application for the person

How relevant today, drugs against worms in humans? What kind of creatures these worms, what are modern methods of treatment? We will try to answer these questions, since ignorance in this area is undesirable. Imagine a mummy, which is misleading in k...

What to do if you cracked skin on hands?

What to do if you cracked skin on hands?

Each of us at least once in a lifetime encounter with a small, but very, when the crack the skin on the hands. At this time there are wounds of different sizes, which hurt and cause inconvenience, especially when in contact with water or detergents. ...

Spray Macho man - the key to a proper relationship between the two spouses

Spray Macho man - the key to a proper relationship between the two spouses

Male impotence is a pathological condition associated with abnormal physiological capacity of the penis to reginout and bring sexual partner pleasure in bed.sex impotenceimpotence may not men to pass unnoticed – it usually spoils his nervous sy...

zoledronic acid in Oncology reviews

Osteoporosis: it is more effective and effectiveness

The Preparations of zoledronic acid is widely used in the treatment of osteoporosis in patients of different age groups. The correct reception of the medicine helps to normalize metabolic processes. In the short term indicators stabiliziruemost to biological human norms, and then maintained in this condition for a long period. On average, under the influence of drugs set the parameters of metabolic processes, characteristic of premenopausal women. For one annual infusion does not progress reduce the number of metabolic markers in tissues of the skeletal system.

Pharmacokinetics

Treatment of zoledronic acid involves the intravenous infusion is dissolved in a special liquid powder (in water acid is practically insoluble). Immediately after the procedure, there is a sharp increase in the concentration of the substance in the blood plasma. The highest indicator is fixed to the end of the infusion. The decay of concentration is also fast, only a day zoledronic acid decreases in concentration and reaches no more than one percent relative to the maximum value obtained at the time of infusion. A long time interval in the circulatory system substance is present in an amount of 0.1% of the maximum.

The cumulative effect is not observed. The use of zoledronic acid should be strictly obey the rules of use of the drug. This takes into account that the substance of the body is excreted in the urine. The three-step process. The first step – 0,25-1,87 hours, then a longer second. Overall assessment of half-life – 146 hours.

When will help?

The Use of zoledronic acid is indicated for:

  1. Osteoporosis, diagnosed in the period after menopause.
  2. Osteoporosis caused by long-term administration of corticosteroids.
  3. Osteodystrophy, causing the deformation.

In the period after menopause zoledronic acid helps prevent fractures induced decrease in skeletal strength.

the use of zoledronic acid

The Drugs based on this compound showed good results as an element of the therapeutic course, with an excess of calcium in your body. It is often observed on the background of malignant neoplastic processes, metastatic carcinoma in bone tissue.

Categorically

As indicated in the instructions, zoledronic acid is not used if a patient has an allergic reaction to a substance, or hypersensitivity to it. It is unacceptable to undergo treatment in the period of carrying a child, feeding the baby's chest. Zoledronic acid is not permitted for the treatment of minor patients and individuals in the body which includes a lack of calcium. It is impossible to apply the composition, if the kidneys are not active, the clearance of creatine is estimated at 35 ml/min or less.

You Can, but very carefully

Manual of zoledronic acid provides guidance for use of the drug in severe liver diseases, but only when you can continually monitor the patient and remove the performance indicators that are important for life. Similar conditions apply to the use of medication when aspirinova bronchial asthma. In such cases a doctor firstanalyzes how big is the risk to the patient and what positive aspects associated using this medication, then introduces the patient of possible dangers and consequences of treatment. Only on the basis of detailed analysis can make the final decision on the reasonableness of the use of zoledronic acid in this case.

zoledronic acid

Special occasion

Zoledronic acid can not be used to treat minor patients, since there are no official data, allowing to speak about its security. There is no information confirming the effectiveness of drugs based on this substance. For similar reasons, the tool is not used in the treatment of pregnant women, nursing mothers. There is no information about what could trigger the consequences of the use of the drug in patients with impaired renal function and liver. In General treatment with acid is not recommended, although occasionally doctors may suggest this option, but just reasoning it is really important arguments.

According to reviews, zoledronic acid is used to treat individuals who are diagnosed with renal anomalies. If the creatine clearance is greater than the parameter 35 ml/min, we can safely use the medication, without correcting the standard pattern.

Negative effects

It is Known that the use of the described drug can cause a negative response. Of medical practice is well established, the following is possible with the use of zoledronic acid side effects:

  • Sick, dizzy.
  • Patient worried, anxious.
  • Temporary clouding of consciousness.
  • Sleep disturbance.
  • Shortness of breath and cough.
  • Violation of stool, pain in the abdomen.
  • Inflammation of the mucosa.
  • Vision Deterioration.

Formulated by experts reviews: zoledronic acid can cause taste disturbances, lethargy, anorexia, glaucoma. Cases are known when the drug provoked skin rashes, renal failure, allergic reactions. Under the influence of the active component may be a violation of pressure (in the upper or lower direction relative to the norm), the weakening of the cardiac rhythm.

More Often negative response of the body felt in the beginning of the therapeutic course. As can be seen from the feedback of patients, zoledronic acid first becomes cause fever, pain that take place after 72 hours after the first administration of the substance.

zoledronic acid in Oncology patients

How to use?

The Most frequently used drug, as mentioned above, in the treatment of osteoporosis and in Oncology. Zoledronic acid should be used strictly under supervision of a doctor. It is unacceptable to use this connection at home. Not permitted to consume madridsta based on the acid.

According to the rules, the substance is injected into the vein, the infusion lasts for more than a quarter of an hour. Preparation of the solution must occur in absolute sterility. The standard dose involves the dilution of 4 g of substance in 5 ml of liquid. The finished product is mixed with 100 ml of saline or dextrose (concentration – 5 %). The finished product should be used immediately, storage shall not be allowed. The composition is recommended to apply once a year.

Significant aspects

As you can see from the reviews of patients, zoledronic acid in Oncology, osteoporosis treatment applies strictly controlled by the doctor, otherwise there is a high likelihood of side effects and deterioration of the patient. Before the procedure the doctor ensures that the patient has consumed a sufficient amount of drinking. It is required in the treatment process. It is important to ensure the flow of liquid in adequate amounts, avoiding an overabundance, so the process of drinking takes place under the supervision of a doctor, and specific quantities are calculated taking into account individual peculiarities of the patient.

It is Necessary to analyze the diet of the patient. If the food is not getting enough vitamin D, calcium, it is important to ensure an additional inflow of these compounds to prevent their failure.

Too many!

With the introduction of too many showing signs of overdose. Zoledronic acid negatively affects the functioning of the kidneys, laboratory tests show a shortage of magnesium, phosphorus, calcium deficiency. The main task of the doctor – symptomatic treatment to the shortage minerals in body tissues. Injections patient is urgently administered magnesium sulfate, calcium gluconate, potassium, sodium phosphate. Calcium can be used orally.

zoledronic acid

Match: how?

Is not valid in the syringe to mix zoledronic acid and other substances compounds. In the use of the drug and some types of diuretics there is a possibility of deficiency of minerals, so it is important to monitor the patient's condition. A similar effect is observed when combined with aminosilicone.

If diagnosed plasmacytoma in a generalized form, as a therapeutic course involves the use of“Thalidomide”, the use of zoledronic acid with a high degree of probability can cause failure of renal function.

Unacceptable during treatment can not drink alcohol.

Note!

The solvent of zoledronic acid is not allowed to use a substance which is composed of calcium cations. In the process of therapy the doctor should monitor the patient's condition, to verify the concentration in the body of phosphorus, calcium, magnesium. You should regularly take the analysis to the clearance of creatine. It is important to inform the patient how been the lack of minerals in the body, how to behave at the first suspicion of such changes. If the patient belongs to a risk group for deficiency of minerals, it is important to closely monitor the status of the client.

At the beginning of the therapeutic course can take specialized drugs to ease side effects after the first injection. The most common and effective – substances based on ibuprofen and paracetamol. First on drugstore shelves are presented under trade names “disappointed”, “Moment”, the second category – “Drunk” and its analogs.

zoledronic acid side

Because zoledronic acid may have a negative effect on the Central nervous system when undergoing treatment with this drug is reasonable to refuse transportation and to avoid tasks that require increased attentiveness, concentration.

Counterparts

Zoledronic acid-the active component of pharmaceutical products:

  • “Resorba”;
  • “the Aklast”.

In some cases, experts advise to stop the choice on the drug “Ballast”.

Choosing a specific name, you should consult with your doctor.

In some cases, zoledronic acid can be replaced by other means from the group of bisphosphonates. On pharmacy shelves they are presented under trade names “Bonefos”, “Bonviva”. A good reputation you'll be the cure “Ibandronate-Teva”. To produce self-change written out of zoledronic acid for these funds is in any case can not, be sure to coordinate this step with your doctor.

Fight cancer: reaching a new level

According to reviews, zoledronic acid in Oncology was hardly a breakthrough. Special attention is given to the tool on the shelves of pharmacies presented as “Resscan”. This drug – the first on the planet from the category of commercial radiopharmaceutical designed specifically to detect abnormalities of the skeletal system by modern nuclear technology. The basic substance “Resscan” – consider zoledronic acid. From all other radiopharmaceutical drugs “Resscan” different major component. As targeted media, the manufacturer has applied the acid that has the highest level (if you compare with other bisphosphonates) affinity for areas of high bone resorption. It helps to quickly and accurately establish the presence of metastases to localize them. “Resscan” shows reliable results in the study of patients with different types of tumors, triggered by different factors and have developed in different areas of the body.

Bone scan

Using ‘Resscan”, you can quickly detect lytic metastasis, conducting initial diagnosis. This is especially true if the tumor in the prostate gland. On the basis of the obtained in the course of the study information, you can write zoledronic acid in the form of injection. This allows you to start treatment promptly, and thus achieve the maximum effect, to prevent the emergence of metastases in the future.

zoledronic acid manual

Using ‘Resscan”, can differentially diagnose degenerative changes caused by cancer and other factors. The accuracy of such information – pledge well-chosen therapeutic course. Diagnostic methods, involving the use of “Resscan”, help to precisely identify all the features of the patient's condition, if destructive processes in bone tissue are associated with factors that have nothing to do with cancer. This makes the tool an important assistant doctor in identifying features of the articular pathologies of the spine.

Oncology: how does it work?

The Use of zoledronic acid in therapy of cancer patients shows good results in the timely start of the course. In some cases, drugs on this substance is the main component of therapy, but they can act as a secondary item recovery period after chemotherapy.

Like other bisphosphonates, zoledronic acid simultaneously suppresses the proliferation of abnormal cells and prevents the process of bone destruction. When this was not possible to detect negative changes in body tissues caused by a substance. It is considered that zoledronic acid is safe, if you use it in accordance with the instructions on the contraindications. Indeed, the reception is often fraught with side effects, but they are short-lived and quicklypass, the cumulative effect is not observed.

In the therapy of cancer zoledronic acid is prescribed as the course, the duration of the programme – up to a month. Particular should choose a doctor based on the type of malignancy of the tumor, the patient's condition and response to therapy. In some cases, the duration – up to nine months, a year and a half. The detection of excess calcium in the body reduces the frequency of treatments.

Pros and cons

Reviews indicate that zoledronic acid shows fast positive effect. Cancer is most pronounced positive aspects, if the patient previously underwent chemotherapy.

Many patients treated with this tool, note that the most significant shortcoming – too high a price. Zoledronic acid is from five to fifteen thousand for one bottle. Specific values depend on the manufacturer, the point of sale.


Article in other languages:

AR: https://www.tostpost.com/ar/health/12335-zoledronic-acid-instructions-for-use-analogs-reviews.html

BE: https://www.tostpost.com/be/zdaro-e/22108-zaledronavaya-k-slata-nstrukcyya-pa-zhyvann-analag-vodguk.html

DE: https://www.tostpost.com/de/gesundheit/22114-zoledrons-ure-anwendungshinweise-pendants-bewertungen.html

ES: https://www.tostpost.com/es/la-salud/22132-zoledronovaya-cido-instrucciones-de-uso-an-logos-los-clientes.html

HI: https://www.tostpost.com/hi/health/12352-zoledronic-analogs.html

JA: https://www.tostpost.com/ja/health/12354-zoledronic-acid-instructions-for-use-analogs-reviews.html

KK: https://www.tostpost.com/kk/densauly/22101-zoledron-ysh-yly-oldanu-zh-n-ndeg-n-s-auly-analogtary-p-k-rler.html

PL: https://www.tostpost.com/pl/zdrowie/22054-kwas-zoledronowy-instrukcja-obs-ugi-zamienniki-opinie.html

PT: https://www.tostpost.com/pt/sa-de/22056-o-cido-zoledronic-instru-es-de-utiliza-o-an-logos-coment-rios.html

TR: https://www.tostpost.com/tr/sa-l-k/22110-zoledronic-asit-kullan-m-talimat-e-de-er-yorumlar.html

UK: https://www.tostpost.com/uk/zdorov-ya/22084-zoledronovaya-kislota-nstrukc-ya-po-zastosuvannyu-analogi-v-dguki.html

ZH: https://www.tostpost.com/zh/health/13119-zoledronic-acid-instructions-for-use-analogs-reviews.html






Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."

Comments (0)

This article has no comment, be the first!

Add comment

Related News

How much is to insert the teeth? Dental implants – an alternative way to regain the beauty of the smile

How much is to insert the teeth? Dental implants – an alternative way to regain the beauty of the smile

to find out how much it costs to insert the teeth, give a definition of "implantation" and find out the indications for this procedure. Implantation is the implantation in the jawbone a synthetic tooth root. Currently, dental impl...

Stomach flu: symptoms of rotavirus infection

Stomach flu: symptoms of rotavirus infection

a Disease called influenza, has many versions of the origins and manifestations. For example, there are such species as swine, bird, stomach flu. Symptoms, signs and treatment of the latter will be analyzed in this article.it Shou...

Which is better the contraceptive candles to choose from. Expert advice

Which is better the contraceptive candles to choose from. Expert advice

of Course, most of the female audience is well aware that the spark contraceptive spectrum are classified as drugs chemical contraception. They necessarily contain spermicides – acids that destroy the sperm.How not to make t...

Sinusitis: types, symptoms and treatment

Sinusitis: types, symptoms and treatment

Sinusitis – a very common disease. It is characterized by the development of inflammation in the sinuses. Dangerous disease that can quietly flow into the chronic form and also give complications to the eyes, ears, brain, to...

Interferon during pregnancy

Interferon during pregnancy

Interferon – immune-boosting drug. Its good and harm depends solely on the appropriateness of applying. If the drug really shows, he will benefit. Interferon during pregnancy it is prescribed to protective therapy. It is no ...

Treatment of the fungus Veselka. Traditional recipes with mushroom phallus

Treatment of the fungus Veselka. Traditional recipes with mushroom phallus

Veselka ordinary – it is a fungus that grows to a height of 30 cm and ubiquitous, in deciduous forests in particular. This mushroom is edible, it can even be used in food, although it deals exclusively with young veselok und...