One of the common pathologies of the endocrine nature of diabetes mellitus. Most patients with this diagnosis suffer from the second type of this disease. The disease requires constant treatment and medication. To stimulate the production of insulin in the body can use the drug "Gliclazide". Counterparts funds may have a similar mechanism of therapeutic action or identical composition. To find a substitute for the original medicines have the doctor.
The Drug “Gliclazide” belongs to the sulfonylureas (second generation) and has a pronounced hypoglycemic effect. The drug can be used in the treatment of non-insulin dependent diabetes. The main goal of therapy ‘Gliclazide” is to reduce the level of glucose in the blood. Also normalizes carbohydrate and lipid metabolism. The pharmacy to buy medicine under the name “Gliclazide-AKOS”, “Glidiab-MV”.
The same name active substance positively influences the state of blood vessels, reducing their permeability and preventing the development of atherosclerosis. Long-term use of the drug in diabetic nephropathy provides a significant reduction of proteinuria (presence of protein in the urine). The treatment medium significantly reduced the risk of mural thrombosis.
The Maximum concentration of the main active ingredient in the blood is fixed in 6-12 hours after taking the pills "Gliclazide". Analogues of the drug is also well established, but they have to pick up the doctor individually. In the composition of the original drug active substance is gliclazide modified-release.
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According to the annotation, "Gliclazide" is assigned to persons with a history of diabetes (sugar) 2nd type. Pathology is different from the first type by the fact that in the second case completely cease insulin production by the body. The main reason for the development of the ailment is considered age-related aging. However, the presence of extra pounds and excessive consumption of carbohydrate can also trigger the development of diabetes.
Tablets "Gliclazide" the manual recommends using in the complex therapy for microcirculatory disorders. In the preventive purposes the drug is administered to prevent the development of severe consequences of diabetes: stroke, heart attack, nephropathy, and retinopathy.
It is Forbidden to accept "Gliclazide" (similar drug) in the presence of the following diagnoses:
The Dosage of hypoglycemic drugs is selected by the specialist individually. The daily dose may vary in the range of 30-120 mg of active ingredient depending on the severity of the patient's condition and age. Take the tablets once a day before meals (preferably on an empty stomach).
When skipping taking medication to increase the dosage is not recommended. In some instances, the maximum dosage can reach 320 mg.
Analogues, hypoglycaemic agents, as the original drug, are used only in combination with a low calorie diet, which involves eating minimal amounts of carbohydrates. It is important to control the level of glucose in blood serum before and after eating. Adjust the dosage of the drug after emotional stress or physical exertion.
The Drug can cancel with fever caused by extensive burns, surgical interventions. While admission "Gliclazide" and etanolsodergaszczye medicines, non-steroidal anti-inflammatory drugs there is a risk of hypoglycemia. Ethanol can cause abdominal pain, vomiting, nausea.
Drugs sulfonylureas are considered fundamental in the treatment of diabetes. To significant deficiencies include the development of resistance. A similar situation is observed in 5% of patients, who were transferred to insulin therapy.
The Drug "Gliclazide" the price of which ranges from 130-160 rubles per pack (30 pills), you can replace a drug with a similar composition. On the basis of gliclazide release medicaments with modified release. Effective are the following analogues of the original medicines:
Based formulations of gliclazide have a positive effect on the microcirculation, hematological, hemostatic system. This is extremely important for patients with diabetes of the 2nd type. To pick up the medicines for stimulating the production of insulin needs attending. Note that this therapeutic effect entails an increase in body mass.
Hypoglycemic agent is available in tablet form. One tablet contains 80 mg of the main active ingredient gliclazide. As auxiliary components, use milk sugar, magnesium stearate, povidone. Manufacturer – the Russian pharmaceutical company-produces a product ‘Diazepam MV" modified-release. In these tablets the dosage of active substance reduced to 30 mg. Release occurs within 24 hours.
In individually selected dose. The doctor takes into account the level of glucose in the blood serum, the patient's age and symptoms of the disease. The initial daily dose should not exceed 80 mg. To further increase to 160-320 mg of gliclazide.
“Diabetes" instructions for use recommends for adult patients for whom no effective diet and exercise. The modified-release tablet (MV) should be 1 time per day. The doctor may increase the dosage after testing blood sugar.
Experts say that side effects in patients receiving the drug develop mainly failure to comply with dispensing and General recommendations regarding integrated treatment. Hypoglycaemia – one of the frequent side effects – it is accompanied by symptoms such as increased appetite, arrhythmia, palpitations, fatigue, drowsiness.
From the digestive tract you may receive the following narusheniy:
In rare cases manifest an allergic reaction in the form of itching, hives, redness of the skin. Some signs of side effects of the drug called for its repeal.
Overdose often leads to the development of hypoglycemia, hypoglycemic coma, disturbance of consciousness. To restore the glucose concentration is possible by means of intravenous administration of dextrose (if the patient is unconscious). In that case, if there are clear signs of hypoglycemia, but the patient remains conscious, he must take the small amount of sugar.
Another gipoglikemicheskoe agent, has a pronounced therapeutic effect – “Glidiab”. Instruction manual says that each tablet contains 80 mg of active ingredient gliclazide. One pack contains 60 tablets. The cost of the drug – 110-140 rubles. “Glidiab MV”, the price is 140-170 rubles are assigned patients more often.
The Effect of the drug is based on activation of cells in the pancreas that produce insulin. “Glidiab" capable of restoring first peak of insulin secretion, which distinguishes it from some other means from the group of sulfonylureas.
4 hours after taking the medication is observed a maximum concentration of gliclazide in serum. The drug is absorbed in the gastrointestinal tract almost completely.
“Glidiab" instructions for use Recommends with caution when concurrent therapy with glucocorticoids, calcium antagonists, barbiturates, lithium salts. It will decrease the therapeutic effectiveness of hypoglycemic agent.
Alin Trodden - author of the article, editor
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