“Tubocurarine chloride” is a muscle relaxant drug and has peripheral action. The instructions stated that he was able to block neuromuscular transmission.
The Main component of this drug is tubocurarine chloride, which is contained in a dosage of 0.01 g as additional substances are added glycerol – 0.3 g and a water for injection.
The Medium at a concentration of 1 % is poured into ampoules of 1.5 ml. Then they spread out in packs of 25 pieces. Also, the drug is placed in bottles of 10 ml which are packaged in boxes of 5 pieces.
“Tubocurarine chloride” is not polarizing muscle relaxant, which is able to block neuromuscular transmission. So, it acts on N-holinoretseptora skeletal muscles. The relaxation effect appears gradually and reaches a peak in approximately 5 minutes.
Relaxation of the muscle occurs sequentially. It all starts with the fingers of the upper extremities, followed by the eye muscles, lower limbs, back, and diaphragm. The toning takes place in the reverse order and starts with the muscles of the diaphragm.
The Mechanism of action of «Tubocurarine chloride” releases histamine from the tissues and can provoke muscle spasms in the bronchi.
This drug is used for muscle relaxation during the connection of the patient to artificial lung ventilation (ALV). It is also prescribed for pharmacological or electrical induced muscle cramps and at the time of diagnosis of myasthenia gravis.
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In orthopaedic surgery is used for repositioning of bone fragments bone and vpravlenie dislocation. In psychiatry for the prevention of schizophrenia and in the treatment of seizures. And in the neuro - epileptic statuses and convulsions of other origin.
It is forbidden to use if you are hypersensitive and hypersensitivity to the components included in the composition. Also "Tubocurarine chloride" is not prescribed to patients with liver failure system with CKD and the elderly.
The Dosage depends on the type of anesthesia that will be administered to the patient. In the instructions for “Tubocurarine chloride” said his is introduced into the body through intravenous way.
Adults Have the means to provoke temporary paralysis of the muscles of the respiratory tract at the doses in 16-26 mg. To achieve a prolonged exposure to a drug is repeated with reducing the dosage to 2 or 1.5 times. For early termination of the drug is administered ‘Neostigmine”.
In patients after treatment may appear rash, swelling, collapse, bronchospasm, tachycardia and lower blood pressure (arterial). May also cause bradycardia, hypersalivation and allergic manifestations because of liberali of histamine. Less common is heart failure or rhythm disturbances.
If overdose may experience prolonged muscle relaxation. Treatment in this case is carried out by supporting a patency of respiratory passages and the injection of neostigmine or pyridostigmine.
Describes the action to take when the first symptoms of overdose.
The effectiveness of the “Tubocurarine chloride” weaken some substance. These include:
Also reduce the impact of low temperature and hypothermia.
To increase the effect of able anesthetics (inhalation), calcium salts, quinine, some antibiotics (streptomycin, kanamycin, neomycin), and other muscle relaxants. The amplification occurs in hypokalemia.
“Tubocurarine chloride” refers to drugs that affect the peripheral nervous system. Operates mainly in the area of the respiratory nerves and ways. Antidepoliarizutmi is a muscle relaxant.
To Apply the remedy can only doctor who has experience in the use of muscle relaxants in preparation for oxygen therapy and intubation of the respiratory tract.
This drug is not sold in all pharmacies and is sold strictly on prescription of a doctor.
To Store and transport the drug should in a cool and protected from sunlight. Shelf life - 5 years.
After expiration date or improper storage use is prohibited.
As substitutes for “Tubocurarine chloride” make use of the following drugs:
These analogues have the same spectrum. But to replace the drug only after consulting with your doctor.
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Alin Trodden - author of the article, editor
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