The Appearance on the pharmaceutical market new antibiotics with a broad spectrum of effects, such as fluoroquinolones, cephalosporins, has led to the fact that doctors have become extremely rare to appoint aminoglycosides (drugs). The list of medications included in this group is quite extensive and includes such well-known medications as “Penicillin”, “Gentamicin”, “Amikacin”. Until today in the intensive care and surgical wards are still the most popular drugs that is aminoglikozidnyi stimulants.
Aminoglycosides-drugs (drug list will be discussed below), different semi-synthetic or natural origin. This group of antibiotics has a fast and powerful antibacterial effects on the body.
Medicine peculiar to a wide range of actions. Their antimicrobial activity is pronounced against gram-negative bacteria, but significantly reduced in the fight against gram-positive organisms. And absolutely aminoglycosides ineffective against anaerobes.
This group of drugs produces an excellent antibacterial effect thanks to the ability to irreversibly inhibit protein synthesis in sensitive microorganisms at the level of ribosomes. The drugs are active against both proliferating and cells that are at rest. The degree of activity of antibiotics depends entirely on their concentration in the blood serum of the patient.
The Group of aminoglycosides used today is rather limited. This is due to the high toxicity of these medicines. Most often suffer from these drugs the kidneys and hearing.
An Important feature of these tools is their inability to penetrate inside a living cell. Thus, aminoglycosides absolutely powerless in the fight against intracellular bacteria.
These antibiotics are widely used, as mentioned above, surgical practice. And this is no coincidence. Doctors stress the many advantages of the aminoglycosides.
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The effects of drugs on the body has the following positive aspects:
However, in addition to the advantages described above, this group of drugs has disadvantages.
The Disadvantages of aminoglycosides are:
There are several classifications.
So, given the sequence of the introduction into medical practice of aminoglycosides, there are the following generation:
Range of action and resistance klassificeret slightly different aminoglycosides.
Generation of medicines are the following:
1. 1 group includes such drugs: “Drug”, “Kanamycin”, “Monomitsin”, “It”. These medicines help to fight the causative agents of tuberculosis and several atypical bacteria. However, against many gram-negative microorganisms and staphylococci, they are rendered powerless.
2. The representative of the second generation aminoglycosides – cure "Doxycycline". It features great antibacterial activity.
3. More advanced drugs. They have high antibacterial activity. Used against Klebsiella, Enterobacter, Escherichia coli, namely, third-generation aminoglycosides (drugs). The list of medications is as follows:
4. The fourth group includes the drug “Isepamicin”. It is characterized by the ability to effectively deal with Citrobacter, Aeromonas, Nocardia.
In medical practice developed by another classification. It is based on the use of drugs depending on the clinical presentation of disease, the nature of the infection and the method of application.
This classification of aminoglycosides as follows:
The Use of aminoglycosides is advisable to destroy a variety of aerobic gram-negative pathogens. Medications may be used as monotherapy. Often they are combined with beta-lactams.
Aminoglycoside indicated for the treatment of:
Unfortunately, during the treatment of this category of medications the patient may feel a number of adverse effects. The main drawback of medications – this is a high toxicity. That is why only a doctor should prescribe the patient aminoglycosides.
Side effects may occur:
Very rarely, aminoglycosides cause allergic reactions such as skin rashes.
The Described drugs have some restrictions for use. Often contraindicated aminoglycosides (which was...
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Alin Trodden - author of the article, editor
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